Synthetic Conjugated Estrogens A

Synthetic Conjugated Estrogens A is a brand name of conjugated estrogens topical, approved by the FDA in the following formulation(s):

SYNTHETIC CONJUGATED ESTROGENS A (estrogens, conjugated synthetic a - cream; vaginal)

• 
  Manufacturer: TEVA WOMENS
  
  Approval date: November 28, 2008
  
  Strength(s): 0.625MG/GM ^[RLD]

Has a generic version of Synthetic Conjugated Estrogens A been approved?

No. There is currently no therapeutically equivalent version of Synthetic Conjugated Estrogens A available.

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Synthetic Conjugated Estrogens A. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

See also: About generic drugs.

Related Patents

There are no current U.S. patents associated with Synthetic Conjugated Estrogens A.

Related Exclusivities

Exclusivity is exclusive marketing rights granted by the FDA upon approval of a drug and can run concurrently with a patent or not. Exclusivity is a statutory provision and is granted to an NDA applicant if statutory requirements are met.

• Exclusivity expiration dates:
  • November 28, 2011 - NEW PRODUCT
  
  

See also...

• SCE-A Consumer Information (Drugs.com)
• SCE-A Cream Consumer Information (Wolters Kluwer)
• Synthetic Conjugated Estrogens, A Cream Consumer Information (Wolters Kluwer)
• Synthetic Conjugated Estrogens, A vaginal Consumer Information (Cerner Multum)
• Conjugated Estrogens Cream Consumer Information (Wolters Kluwer)
• Premarin Cream Consumer Information (Wolters Kluwer)
• Premarin vaginal Consumer Information (Cerner Multum)
• Conjugated estrogens vaginal Consumer Information (Cerner Multum)

Regulaten Plus

Regulaten Plus may be available in the countries listed below.

Ingredient matches for Regulaten Plus

Eprosartan

Eprosartan mesilate (a derivative of Eprosartan) is reported as an ingredient of Regulaten Plus in the following countries:

• Spain

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Regulaten Plus in the following countries:

• Spain

International Drug Name Search

D-Amine-SR

Generic Name: chlorpheniramine and pseudoephedrine (klor fen EER a meen and soo doe e FED rin)

Brand Names: AccuHist Drops, Allerest Maximum Strength, Brexin L.A., Colfed-A, D-Amine-SR, Dayquil Allergy, Deconamine, Dicel, Dicel Chewables, Dura-Tap/PD, Durafed, Duratuss DA, Dynahist-ER Pediatric, Genaphed Plus, Histade, Histex, Kronofed-A, Kronofed-A-Jr, LoHist-D, Mintex, Neutrahist Drops, Re2+30, Rescon-Ed, Suclor, SudaHist, Sudal-12 Chewable, Sudal-12 Tannate, Sudogest Cold & Allergy, SudoGest Sinus & Allergy, Tavist-DA, Triaminic Cold and Allergy, Triaminic Softchew Cold and Allergy, Triaminic Softchews Allergy Runny Nose and Congestion

What is D-Amine-SR (chlorpheniramine and pseudoephedrine)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine and pseudoephedrine is used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.

Chlorpheniramine and pseudoephedrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about D-Amine-SR (chlorpheniramine and pseudoephedrine)?

There are many brands and forms of this medication available and not all brands are listed on this leaflet.

Do not use chlorpheniramine and pseudoephedrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you are allergic to chlorpheniramine or pseudoephedrine, or if you have severe high blood pressure or coronary artery disease, narrow-angle glaucoma, a stomach ulcer, or if you are unable to urinate.

Do not use this medication during an asthma attack.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine and pseudoephedrine. Older adults may be more likely to have side effects from this medicine. Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

What should I discuss with my healthcare provider before taking D-Amine-SR (chlorpheniramine and pseudoephedrine)?

Do not use chlorpheniramine and pseudoephedrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you are allergic to chlorpheniramine or pseudoephedrine, or if you have:

• 
  

  severe or uncontrolled high blood pressure;

  
  


• 
  

  severe coronary artery disease;

  
  


• 
  

  narrow angle glaucoma;

  
  


• 
  

  a stomach ulcer;

  
  


• 
  

  if you are unable to urinate; or

  
  


• 
  

  if you are having an asthma attack.

  
  

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

• kidney disease;


• liver disease;


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  circulation problems;

  
  


• 
  

  heart disease or high blood pressure;

  
  


• 
  

  overactive thyroid;

  
  


• 
  

  a seizure disorder such as epilepsy;

  
  


• 
  

  asthma, emphysema or chronic bronchitis; or

  
  


• 
  

  urination problems or an enlarged prostate.

  
  

FDA pregnancy category C. It is not known whether chlorpheniramine and pseudoephedrine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether chlorpheniramine and pseudoephedrine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medicine.

Artificially sweetened liquid cold medicine may contain phenylalanine. If you have phenylketonuria (PKU), check the medication label to see if the product contains phenylalanine.

How should I take D-Amine-SR (chlorpheniramine and pseudoephedrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

The chewable tablet must be chewed before swallowing.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

If you need surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cold medicine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include some of the serious side effects listed in this medication guide.

What should I avoid while taking D-Amine-SR (chlorpheniramine and pseudoephedrine)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine and pseudoephedrine. Ask a doctor or pharmacist before using any other cold, allergy, or sleep medicine. Chlorpheniramine and pseudoephedrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

D-Amine-SR (chlorpheniramine and pseudoephedrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  fast or pounding heartbeats;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, nervousness;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  easy bruising or bleeding, unusual weakness; or

  
  


• 
  

  seizure (black-out or convulsions).

  
  

Less serious side effects may include:

• 
  

  blurred vision;

  
  


• 
  

  dry nose or mouth;

  
  


• 
  

  nausea, stomach pain, constipation, loss of appetite;

  
  


• 
  

  dizziness, drowsiness;

  
  


• 
  

  problems with memory or concentration;

  
  


• 
  

  ringing in your ears; or

  
  


• 
  

  feeling restless or excited (especially in children).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 800 FDA 1088.

What other drugs will affect D-Amine-SR (chlorpheniramine and pseudoephedrine)?

Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine.

Tell your doctor about all other medications you use, especially:

• 
  

  mecamylamine (Inversine);

  
  


• 
  

  methyldopa (Aldomet);

  
  


• 
  

  reserpine;

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;

  
  


• 
  

  a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or

  
  


• 
  

  an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), nortriptyline (Pamelor), and others.

  
  

This list is not complete and other drugs may interact with chlorpheniramine and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More D-Amine-SR resources

• D-Amine-SR Use in Pregnancy & Breastfeeding
• D-Amine-SR Drug Interactions
• D-Amine-SR Support Group
• 0 Reviews for D-Amine-SR - Add your own review/rating

• AccuHist Drops Prescribing Information (FDA)


• Biohist LA Sustained-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Deconamine MedFacts Consumer Leaflet (Wolters Kluwer)


• Deconamine SR Controlled-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Duotan Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• QDALL 24-Hour Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

Compare D-Amine-SR with other medications

• Hay Fever
• Sinusitis

Where can I get more information?

• Your pharmacist can provide more information about chlorpheniramine and pseudoephedrine.

Aluspray

Aluspray may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Aluspray

Aluminium

Aluminium is reported as an ingredient of Aluspray in the following countries:

• France

International Drug Name Search

Alergidryl

Alergidryl may be available in the countries listed below.

Ingredient matches for Alergidryl

Chlorphenamine

Chlorphenamine maleate (a derivative of Chlorphenamine) is reported as an ingredient of Alergidryl in the following countries:

• Argentina

International Drug Name Search

Dextrose Injection Infants

Dosage Form: injection, solution
Infant Dextrose 25% 250 mg/mL Injection, USP 10 mL PreFilled Syringe

Description

25% Dextrose Injection, USP is a sterile, nonpyrogenic, hypertonic solution of dextrose in water for injection administered by intravenous injection to restore blood glucose levels in hypoglycemia and as a source of carbohydrate calories. Each milliliter (mL) of fluid contains dextrose, hydrous, 250 mg which delivers 3.4 kcal/gram (0.85 kcal/mL). The solution has an osmolarity of 1.39 mOsmol/mL (calc.). pH is 4.5 (3.2 to 6.5). May contain hydrochloric acid and sodium hydroxide for pH adjustment. The solution contains no bacteriostat, antimicrobial agent or added buffer (except for pH adjustment) and is intended only for use as a single-dose injection. When smaller doses are required the unused portion should be discarded with the entire unit.

25% Dextrose Injection, USP is a dextrose (glucose) and nutrient (carbohydrate) replenisher. Dextrose, USP is chemically designated D-glucose monohydrate, (C6H12O6• H2O), a hexose sugar freely soluble in water.

It has the following structural formula:

The syringe is molded from a specially formulated polypropylene. Water permeates from inside the container at an extremely slow rate which will have an insignificant effect on solution concentration over the expected shelf life. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the syringe material.

Clinical Pharmacology

When administered intravenously, this solution restores blood glucose levels in hypoglycemia and provides a source of carbohydrate calories. Carbohydrate in the form of dextrose may aid in minimizing liver glycogen depletion and exerts a protein-sparing action. Dextrose injection undergoes oxidation to carbon dioxide and water. 25% Dextrose Injection, USP provides a concentrated solution sufficiently nonirritating for slow intravenous injection to infants for terminating acute symptomatic episodes of hypoglycemia in the neonate and in older infants (fasting blood glucose below 40 mg/100 mL). Values as low as 20 mg/100 mL are not uncommon in normal asymptomatic infants the first few days of life (longer in premature infants).

Symptoms of hypoglycemia in the newborn and small infants may be difficult to evaluate and convulsions often are the first or only recognized manifestation of depressed blood glucose levels. Because of widely varied etiology, the precise cause may be difficult to establish. Hypoglycemia (deficient blood glucose) due to organic or functional hyperinsulinism, may be only temporarily abated by administration of dextrose (glucose) and may rebound to hypoglycemia levels as release of additional insulin is evoked. In addition to various other causes, an idiopathic form of hypoglycemia in infancy has been described, as well as occasional transitory hypoglycemia in the neonatal period which disappears in later infancy. Fetal hyperinsulinism in response to maternal hyperglycemia of diabetic mothers has been observed. Occasionally convulsions associated with severe hypoglycemia are observed in infants of diabetic mothers.

Since glucose is the only sugar utilized for metabolic requirements of human neural tissue, it is essential to restore deficient blood glucose levels from any cause in order to prevent or correct central nervous system dysfunction.

Indications and Usage

25% Dextrose Injection is indicated in the treatment of acute symptomatic episodes of hypoglycemia in the neonate or older infant to restore depressed blood glucose levels and control symptoms. Other drugs, such as epinephrine and glucagon, should be considered in patients unresponsive or intolerant to dextrose (glucose). Oral feeding of dextrose may be necessary in infants with frequently recurring hypoglycemic episodes or to prevent recurrences due to hyperinsulinemia.

25% Dextrose Injection also provides a minimal source of carbohydrate calories.

Contraindications

A concentrated dextrose solution should not be used when intracranial or intraspinal hemorrhage is present.

Warnings

25% Dextrose Injection, USP is hypertonic and may cause phlebitis and thrombosis at the site of injection.

Significant hyperglycemia and possible hyperosmolar syndrome may result from too rapid administration. The physician should be aware of the symptoms of hyperosmolar syndrome, such as loss of consciousness.

Precautions

Frequent monitoring of serum glucose concentrations is required when intravenous dextrose is given to pediatric patients, particularly neonates and low birth weight infants. Do not administer unless the solution is clear and seal is intact. Discard unused portion. Solutions containing dextrose should be used with caution in infants of diabetic mothers except as may be indicated in neonates who are hypoglycemic.

Care should be exercised to insure that the needle is well within the lumen of the vein and that extravasation does not occur. If thrombosis should occur during administration, the injection should be stopped and corrective measures instituted.

Concentrated dextrose solutions should not be administered subcutaneously or intramuscularly.

Carcinogenesis, Mutagenesis, Impairment of Fertility:

Studies with 25% dextrose solutions in polypropylene syringes have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility.

Pregnancy Category C.

Animal reproduction studies have not been conducted with dextrose. It is also not known whether dextrose can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Dextrose should be given to a pregnant woman only if clearly needed.

Adverse Reactions

Hyperosmolar syndrome, resulting from excessively rapid administration of concentrated dextrose may cause mental confusion and/or loss of consciousness.

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures, and save the remainder of the fluid for examination if deemed necessary.

Overdosage

In the event of overdosage (hyperglycemia) during therapy, re-evaluate the patient and institute appropriate corrective measures. See WARNINGS and PRECAUTIONS.

Dosage and Administration

When possible, glucose concentrations of greater than 12% should be administered by central vein to reduce the risk for phlebitis and thrombosis. 25% Dextrose Injection, USP is administered only by slow intravenous injection. The dosage and constant infusion rate of intravenous dextrose must be selected with caution, particularly in neonates and low birth

weight infants, because of the increased risk of hyperglycemia/ hypoglycemia. In the neonate, an injection of 250 to 500 mg (1 to 2 mL)/kg/dose (5 to 10 mL of 25% dextrose in a 5 kg infant) is recommended to control acute symptomatic hypoglycemia (tremors, convulsions,etc.). Larger or repeated single doses (up to 10 or 12 mL of 25% dextrose) may be required in severe cases or older infants. A specimen for blood glucose determination should be taken before injecting the dextrose. In such emergencies, dextrose should be administered promptly without awaiting pretreatment test results. Subsequent continuous intravenous infusion of 10% dextrose injection may be needed to stabilize blood glucose levels. Further treatment should be guided by evaluation of the underlying disorder. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.

How Supplied

25% Dextrose Injection, USP is supplied in single-dose containers as follows:

List No. Container	Size
1775 Ansyr          Plastic Syring	10 mL

Store at controlled room temperature 15° to 30°C (59° to 86°F). [See USP.]

July, 2004


©Hospira 2004

EN-0271

Printed in USA


HOSPIRA, INC.

LAKE FOREST, IL 60045 USA

Sample Package Label

INFANT DEXTROSE   dextrose   injection, solution

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 52584-775 (0409-1775) Route of Administration INTRAVENOUS DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Dextrose Monohydrate (Dextrose) Dextrose Monohydrate 250 mg  in 1 mL

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 52584-775-10 1 SYRINGE In 1 BAG contains a SYRINGE 1 10 mL In 1 SYRINGE This package is contained within the BAG (52584-775-10)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NDA	NDA019445	07/01/2010

Labeler - General Injectables & Vaccines, Inc (108250663)

Revised: 07/2010General Injectables & Vaccines, Inc

More Dextrose Injection Infants resources

• Dextrose Injection Infants Use in Pregnancy & Breastfeeding
• Dextrose Injection Infants Drug Interactions
• Dextrose Injection Infants Support Group
• 0 Reviews for Dextrose Injection Infants - Add your own review/rating

Compare Dextrose Injection Infants with other medications

• Hypoglycemia

Diflucan

Generic Name: fluconazole (Oral route)

floo-KON-a-zole

Commonly used brand name(s)

In the U.S.

• Diflucan

In Canada

• CanesOral

Available Dosage Forms:

• Powder for Suspension


• Tablet


• Capsule

Therapeutic Class: Antifungal

Chemical Class: Triazole

Uses For Diflucan

Fluconazole is used to treat serious fungal or yeast infections, such as vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of abdomen or stomach], and infections that may occur in different parts of the body), or fungal (cryptococcal) meningitis. This medicine works by killing the fungus or yeast, or preventing its growth.

Fluconazole is also used to prevent candidiasis in patients having bone marrow transplants who receive cancer or radiation treatment.

This medicine is available only with your doctor's prescription.

Before Using Diflucan

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of fluconazole in children 6 months to 13 years of age. However, safety and efficacy have not been established in infants younger than 6 months of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fluconazole in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving fluconazole.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Alfuzosin


• Astemizole


• Bepridil


• Cisapride


• Clozapine


• Crizotinib


• Dasatinib


• Dronedarone


• Granisetron


• Lapatinib


• Levomethadyl


• Lumefantrine


• Mesoridazine


• Nilotinib


• Ondansetron


• Pimozide


• Quetiapine


• Salmeterol


• Sorafenib


• Sparfloxacin


• Sunitinib


• Terfenadine


• Thioridazine


• Vardenafil


• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acenocoumarol


• Ajmaline


• Alprazolam


• Amiodarone


• Amisulpride


• Amitriptyline


• Amoxapine


• Anisindione


• Apomorphine


• Aprindine


• Arsenic Trioxide


• Asenapine


• Atorvastatin


• Azithromycin


• Bretylium


• Cerivastatin


• Chloral Hydrate


• Chloroquine


• Chlorpromazine


• Ciprofloxacin


• Citalopram


• Clarithromycin


• Clomipramine


• Clopidogrel


• Colchicine


• Desipramine


• Dibenzepin


• Dicumarol


• Dihydroergotamine


• Disopyramide


• Dofetilide


• Dolasetron


• Doxepin


• Droperidol


• Enflurane


• Eplerenone


• Ergoloid Mesylates


• Ergonovine


• Ergotamine


• Erythromycin


• Everolimus


• Fentanyl


• Flecainide


• Fluoxetine


• Foscarnet


• Gatifloxacin


• Gemifloxacin


• Halofantrine


• Haloperidol


• Halothane


• Hydroquinidine


• Ibutilide


• Iloperidone


• Imipramine


• Isoflurane


• Isradipine


• Levofloxacin


• Lidoflazine


• Lopinavir


• Lorcainide


• Lovastatin


• Mefloquine


• Methylergonovine


• Moxifloxacin


• Nevirapine


• Nitrofurantoin


• Norfloxacin


• Nortriptyline


• Octreotide


• Ofloxacin


• Paliperidone


• Pazopanib


• Pentamidine


• Perflutren Lipid Microsphere


• Phenindione


• Phenprocoumon


• Pirmenol


• Posaconazole


• Prajmaline


• Probucol


• Procainamide


• Prochlorperazine


• Promethazine


• Propafenone


• Protriptyline


• Quinidine


• Quinine


• Ranolazine


• Rifabutin


• Risperidone


• Sertindole


• Simvastatin


• Sirolimus


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sotalol


• Spiramycin


• Sulfamethoxazole


• Sultopride


• Telavancin


• Telithromycin


• Tetrabenazine


• Tolvaptan


• Toremifene


• Trazodone


• Triazolam


• Trifluoperazine


• Trimethoprim


• Trimipramine


• Vandetanib


• Vasopressin


• Vemurafenib


• Voriconazole


• Warfarin


• Zolmitriptan


• Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil


• Amlodipine


• Atevirdine


• Carbamazepine


• Celecoxib


• Cimetidine


• Cyclosporine


• Etravirine


• Felodipine


• Fosphenytoin


• Glimepiride


• Losartan


• Methadone


• Midazolam


• Nicardipine


• Nifedipine


• Omeprazole


• Phenytoin


• Prednisone


• Ramelteon


• Rifampin


• Rifapentine


• Rosuvastatin


• Saquinavir


• Tacrolimus


• Tipranavir


• Tretinoin


• Trimetrexate


• Valdecoxib


• Vincristine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Electrolyte problems (mineral imbalance) or


• Heart disease—Use with caution. These conditions may increase your chance of having heart rhythm problems and make the effects of this medicine worse.

• Fructose intolerance (rare hereditary problem) or


• Galactose intolerance (rare hereditary problem) or


• Glucose-galactose malabsorption (rare hereditary problem) or


• Lapp lactase deficiency (rare hereditary problem) or


• Sucrase-isomaltase deficiency (rare hereditary problem) or


• Any condition that makes it hard for you to digest sugars or dairy products—Use with caution. The capsule form of this medicine contains lactose (milk sugar) and the oral liquid contains sucrose (table sugar), which can make these conditions worse.

• Heart rhythm problems (e.g., QT prolongation) or


• Liver disease—Use with caution. May make these conditions worse.

• Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of fluconazole

This section provides information on the proper use of a number of products that contain fluconazole. It may not be specific to Diflucan. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

You may take this medicine with or without food.

Shake the oral liquid well before each use. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (suspension or tablets):
  
  • For cryptococcal meningitis:
    
    • Adults and teenagers—400 milligrams (mg) on the first day, followed by 200 mg once a day for at least 10 to 12 weeks. Your doctor may increase your dose if needed.
    
    
    • Children 6 months to 13 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 12 milligrams (mg) per kilogram (kg) of body weight on the first day, followed by 6 milligrams (mg) per kilogram (kg) of body weight once a day, for at least 10 to 12 weeks.
    
    
    • Infants younger than 6 months of age—Use and dose must be determined by your doctor.
    
    
  
  
  • For esophageal candidiasis:
    
    • Adults and teenagers—200 milligrams (mg) on the first day, followed by 100 mg once a day for at least 3 weeks. Your doctor may increase your dose if needed.
    
    
    • Children 6 months to 13 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 6 milligrams (mg) per kilogram (kg) of body weight on the first day, followed by 3 milligrams (mg) per kilogram (kg) of body weight once a day, for at least 3 weeks.
    
    
    • Infants younger than 6 months of age—Use and dose must be determined by your doctor.
    
    
  
  
  • For oropharyngeal candidiasis:
    
    • Adults and teenagers—200 milligrams (mg) on the first day, followed by 100 mg once a day for at least 2 weeks.
    
    
    • Children 6 months to 13 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 6 milligrams (mg) per kilogram (kg) of body weight on the first day, followed by 3 milligrams (mg) per kilogram (kg) of body weight once a day, for at least 2 weeks.
    
    
    • Infants younger than 6 months of age—Use and dose must be determined by your doctor.
    
    
  
  
  • For other infections that may occur in different parts of the body:
    
    • Adults and teenagers—Doses of up to 400 milligrams (mg) per day.
    
    
    • Children 6 months to 13 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 6 to 12 milligrams (mg) per kilogram (kg) of body weight per day.
    
    
    • Infants younger than 6 months of age—Use and dose must be determined by your doctor.
    
    
  
  
  • For urinary tract infections or peritonitis:
    
    • Adults—50 to 200 milligrams (mg) per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For vaginal candidiasis:
    
    • Adults—150 milligrams (mg) taken as a single dose.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For prevention of candidiasis during bone marrow transplantation:
    
    • Adults—400 milligrams (mg) once a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

The mixed oral liquid should be kept in the refrigerator or at room temperature and used within 14 days. Do not freeze.

Precautions While Using Diflucan

It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

If your or your child's symptoms do not improve, or if they become worse, check with your doctor. Continue to take this medicine as directed.

You or your child should not use astemizole (Hismanal®), cisapride (Propulsid®), pimozide (Orap®), quinidine (Cardioquin®), or terfenadine (Seldane®) while receiving this medicine because of the risk of unwanted side effects.

Using this medicine for a long time or using it too much while you are pregnant (especially during the first trimester) can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine may rarely cause serious liver problems. Stop using this medicine and check with your doctor right away if you or your child are having more than one of these symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

This medicine may rarely cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop taking this medicine and call your doctor right away if you or your child have a rash, itching, hives, hoarseness, trouble with breathing, trouble with swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions can occur in certain people during treatment with this medicine. Check with your doctor right away if you or your child start having a skin rash, itching, or any other skin changes while you are using this medicine.

This medicine may rarely cause a heart rhythm problem called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Check with your doctor right away if you or your child have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Diflucan Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Abdominal or stomach pain


• chills


• clay-colored stools


• cough


• dark urine


• diarrhea


• difficulty with swallowing


• dizziness


• fast heartbeat


• fever


• general feeling of tiredness or weakness


• headache


• hives


• itching


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• light-colored stools


• loss of appetite


• nausea and vomiting


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• shortness of breath


• skin rash


• stomach pain, continuing


• tightness in the chest


• unpleasant breath odor


• unusual tiredness or weakness


• upper right abdominal or stomach pain


• vomiting of blood


• wheezing


• yellow eyes and skin

Incidence not known

• Black, tarry stools


• blistering, peeling, or loosening of the skin


• chest pain or discomfort


• convulsions


• decreased urine


• dry mouth


• fainting


• hoarseness


• increased thirst


• irregular or slow heart rate


• joint or muscle pain


• loss of bladder control


• lower back or side pain


• mood changes


• muscle pain or cramps


• muscle spasm or jerking of all extremities


• numbness or tingling in the hands, feet, or lips


• painful or difficult urination


• pale skin


• red skin lesions, often with a purple center


• red, irritated eyes


• sore throat


• sores, ulcers, or white spots in the mouth or on the lips


• sudden loss of consciousness


• swollen glands


• unusual bleeding or bruising

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Fearfulness, suspiciousness, or other mental changes


• seeing, hearing, or feeling things that are not there

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Acid or sour stomach


• belching


• change in taste or bad, unusual, or unpleasant (after) taste


• heartburn


• indigestion


• stomach discomfort or upset

Incidence not known

• Hair loss or thinning of the hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Diflucan side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Diflucan resources

• Diflucan Side Effects (in more detail)
• Diflucan Use in Pregnancy & Breastfeeding
• Drug Images
• Diflucan Drug Interactions
• Diflucan Support Group
• 26 Reviews for Diflucan - Add your own review/rating

• Diflucan Prescribing Information (FDA)


• Diflucan Consumer Overview


• Diflucan Monograph (AHFS DI)


• Diflucan MedFacts Consumer Leaflet (Wolters Kluwer)


• Fluconazole Prescribing Information (FDA)


• Fluconazole Professional Patient Advice (Wolters Kluwer)

Compare Diflucan with other medications

• Blastomycosis
• Bone Marrow Transplantation
• Candida Infections, Systemic
• Candida Urinary Tract Infection
• Chronic Mucocutaneous Candidiasis
• Coccidioidomycosis
• Coccidioidomycosis, Meningitis
• Cryptococcal Meningitis, Immunocompetent Host
• Cryptococcal Meningitis, Immunosuppressed Host
• Cryptococcosis
• Esophageal Candidiasis
• Fungal Infection Prophylaxis
• Fungal Infection, Internal and Disseminated
• Fungal Peritonitis
• Fungal Pneumonia
• Histoplasmosis
• Onychomycosis, Fingernail
• Onychomycosis, Toenail
• Oral Thrush
• Tinea Versicolor
• Vaginal Yeast Infection